Product Description

MYO6 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62408-50, BS62408-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The myosin family of motor proteins drive ATP-dependent actin-based motility in eukaryotic cells and contain a conserved amino-terminal motor domain. Myosin VI is an unconventional minus-end-directed myosin involved in the transport of vesicles and organelles within the cell, endocytosis, and organelle biogenesis. The movement of myosin VI and its cargo along actin filaments is unique among myosin family members in its mechanism, its tail domain structure allows it to take larger than predicted steps along the actin filament. Myosin VI has been shown to regμlate the polarized delivery of proteins to specialized subcellμlar locations, including the delivery of EGFR to the leading edge of migrating cells, as well as the delivery of specialized axonal proteins in neurons. Myosin VI has also been shown to mediate activity of the tumor suppressor p53 during DNA damage.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: Unconventional myosin-VI, Unconventional myosin-6, MYO6, KIAA0389

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human MYO6.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: MYO6 polyclonal antibody detects endogenous levels of MYO6 protein.

Molecular Weight: ~ 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UM54

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only