Product Description

Myosin 14 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62405-50, BS62405-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regμlate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb, and IIc, respectively. While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATP hydrolysis, their cellμlar functions do not appear to be redundant and they have different subcellμlar distributions. The carboxy-terminal tail domain of myosin II is important in isoform-specific subcellμlar localization. Research studies have shown that phosphorylation of myosin IIa at Ser1943 contributes to the regμlation of breast cancer cell migration.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: Myosin-14, Myosin heavy chain 14, Myosin heavy chain, non-muscle Iic, Non-muscle myosin heavy chain Iic, NMHC II-C, MYH14, KIAA2034, FP17425

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human Myosin 14.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: Myosin 14 polyclonal antibody detects endogenous levels of Myosin 14 protein.

Molecular Weight: ~ 228 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q7Z406

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only