Myosin Heavy Chain, Smooth Muscle (SMMHC) Mouse Monoclonal Antibody (PT0614) - RA11727

Myosin Heavy Chain, Smooth Muscle (SMMHC) Mouse Monoclonal Antibody (PT0614) Size: 50μL, 100μL Catalogue Numbers: RA11727-50, RA11727-100 Citations, Manuals and MSDS Available upon request. Background: myosin heavy chain 11 (MYH11) Homo sapiens The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv (16) (p13q22) ] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alter Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Applications: IHC-p; IF (paraffin section) ; WB Species Cross-Reactivity: Human GeneID (Human): 4629 SWISS: P35749 Source: Mouse Research Use Only