Product Description

Myotubμlarin (Y290) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2971-50, BS2971-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Human MTM1, a 603 amino-acid protein, is mutated in myotubμlar myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubμlarin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regμlation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubμlarin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regμlating PI 3-K activity and by facilitating the degradation of PI 3-P.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC

Alternate Names: Myotubμlarin, MTM1, CG2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 256-3111 of Human Myotubμlarin.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Myotubμlarin (Y290) polyclonal antibody detects endogenous levels of Myotubμlarin protein.

Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13496

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only