Product Description

Na+ CP type α-Pan (E1476) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3558-50, BS3558-100

Sizes: 50µl, 100µl

Swiss-Prot: Q15858

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: Voltage-gated Na+ channels regulate the permeability of excitable cells to sodium ions. During the propagation of an action potential, Na+ channels allow an influx of sodium ions, which rapidly depolarize the cell. The sodium channel protein is comprised of one α subunit and two β subunits. The Na+ CP type I and Na+ CP type IIα subunits are expressed in adult brain. Na+ CP type IIIα is expressed in embryonic brain, but not in adult brain. Na+ CP type IIIβ is a 215 amino acid, single-pass type I membrane protein that modulates sodium channel gating kinetics and inactivates the channel opening more slowly than the Iβ subunit. It has an extracellular N-terminal domain, an N-terminal signal sequence, a single membrane-spanning region and a C-terminal cytoplasmic region.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Na+ CP type α-pan (E1476) polyclonal antibody detects endogenous levels of Na+ CP type α-pan protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Na+ CP type α-pan (E1476) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 226 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; SCN9A; NENA

Immunogen: Synthetic peptide, corresponding to amino acids 1442-1496 of Human Na+ CP type α-pan.

Conjugate: Unconjugated

Modification: Unmodified