Na+ CP type IVα Polyclonal Antibody-BS5812

Na+ CP type IVα Polyclonal Antibody

Catalogue Numbers: BS5812-50, BS5812-100

Sizes: 50µl, 100µl

Alternative Name: Sodium channel protein type 4 subunit alpha; SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; SCN4A

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P35499

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disulfide-linked β2 subunit. The two β subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. The β1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, β1 and β2 are highly expressed in Purkinje cells, and β1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Na+ CP type IVα polyclonal antibody detects endogenous levels of Na+ CP type IVα protein.

Bioworld Molecular Weight: ~ 208 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Na+ CP type IVα polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 472-517 of Human Na+ CP type IVα.

Conjugate: Unconjugated

Modification: Unmodified