Product Description

Na+ CP type IXα Polyclonal Antibody

Catalogue Numbers: BS5813-50, BS5813-100

Sizes: 50µl, 100µl

Alternative Name: Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; SCN9A; NENA

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15858

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IXα, also known as SCN9A (sodium channel protein type 9 subunit α), NENA, PN1, Nav1.7 or ETHA, is a 1,988 amino acid multi-pass membrane protein that belongs to the voltage-gated sodium channel family. Expressed in dorsal root ganglion, smooth muscle cells and in the central and peripheral nervous system, Na+ CP type IXα functions to mediate the voltage-dependent sodium ion permeability of membranes, specifically forming a sodium-selective ion channel through which sodium may pass. Via its ability to control the flow of sodium in and out of excitable membranes, Na+ CP type IXα plays an important role in the inflammatory pain response. Defects in the gene encoding Na+ CP type IXα are the cause of primary erythermalgia, autosomal recessive congenital indifference to pain and paroxysmal extreme pain disorder (PEPD), all of which are genetic pain disorders.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Na+ CP type IXα polyclonal antibody detects endogenous levels of Na+ CP type IXα protein.

Bioworld Molecular Weight: ~ 226 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Na+ CP type IXα polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 702-747 of Human Na+ CP type IXα.

Conjugate: Unconjugated

Modification: Unmodified