Product Description

NALP12 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67033-50, MB67033-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Plays an essential role as an potent mitigator of inflammation.Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways .Functions as a negative regμlator of NOD2 by targeting it to degradation via the proteasome pathway .In turn, promotes bacterial tolerance.Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity).Acts also as a negative regμlator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue .

Category: Primary Antibody

Reactivity: Mouse

Host: Mouse

Applications: WB

Alternate Names: NALP12, PYPAF7, RNO, NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regμlated by nitric oxide

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human NALP12. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of NALP12 protein.

Molecular Weight: ~ 119 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: E9Q5R7

Product: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only