NALP12 Monoclonal Antibody-MB67033

NALP12 Monoclonal Antibody

Catalogue Numbers: MB67033-50, MB67033-100

Sizes: 50µl, 100µl

Product: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: E9Q5R7

Host: Mouse

Reactivity: Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Plays an essential role as an potent mitigator of inflammation.Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways .Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway .In turn, promotes bacterial tolerance.Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity).Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of NALP12 protein.

Extra Notes: Western blot analysis of NALP12 expression in mouse brain (A) whole cell lysates.

Bioworld Molecular Weight: ~ 119 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: NALP12; PYPAF7; RNO; NACHT, LRR and PYD domains-containing protein 12; Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide

Immunogen: Recombinant fusion protein of human NALP12. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified