Product Description

NCF2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS6214-50, BS6214-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P19878

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB: 1:500~1:2000
IHC/IF: 1:50~1:200

Background: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NCF2 polyclonal antibody detects endogenous levels of NCF2 protein.

Bioworld Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: WesternBlot (WB) analysis of NCF2 polyclonal antibody in extracts from THP1 cells and mouse spleen tissue., Immunohistochemistry (IHC) analysis of NCF2 pAb in paraffin-embedded Human Esophageal Cancer tissue., Immunofluorescence analysis of Hela cells, using NCF2 polyclonal antibody

Alternative Name: 67 a neutrophil oxidase factor; Chronic granulomatous disease autosomal 2; NADPH oxidase activator 2; NCF-2; Ncf2; NCF2; Neutrophil cytosol factor 2; Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; p67phox;

Immunogen: Recombinant full length Human NCF2.

Conjugate: Unconjugated

Modification: Unmodified