Product Description

Nebμlette Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65465-50, BS65465-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nebμlette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebμlin and its expression is abundant in cardiac muscle. Nebμlette defects are assocated with non-familial idiopathic cardiacmyopathy. Nebμlin and nebμlette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebμlette, unlike nebμlin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebμlette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebμlette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Actin binding Z disk protein, bA56H7.1, LIM nebμlette, LNEBL, NEBL, NEBL_HUMAN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Nebμlette:321-420/1014

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: Nebμlette Polyclonal Antibody detects endogenous levels of Nebμlette protein.

Molecular Weight: 116 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O76041

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only