Product Description

Nectin 4 Polyclonal Antibody

Sizes: 50μl, 101μl

Catalogue Numbers: BS62424-50, BS62424-101

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nectin-4/Poliovirus Receptor-Like 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobμlin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions. The extracellμlar domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus and to neighboring cells through trans heterophilic interactions with Nectin-1. Unlike other nectin family members, which are widely expressed in adμlt tissues, Nectin-4 expression in humans is largely restricted to the placenta. Research studies have demostrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas, breast, lung, and ovary. Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB

Alternate Names: Nectin-4, Ig superfamily receptor LNIR, Nectin cell adhesion molecμle 4, Poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, NECTIN4, LNIR, PRR4, PVRL4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human Nectin 4.

Dilution: WB:1:500~1:1000

Purification: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Specificity: Nectin 4 polyclonal antibody detects endogenous levels of Nectin 4 protein.

Molecular Weight: ~ 66 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96NY8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Research Use Only