Product Description

Nectin 4 Polyclonal Antibody

Catalogue Numbers: BS62424-50, BS62424-101

Sizes: 50µl, 101µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: Q96NY8

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB:1:500~1:1000

Background: Nectin-4/Poliovirus Receptor-Like 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions. The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus and to neighboring cells through trans heterophilic interactions with Nectin-1. Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta. Research studies have demostrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas, breast, lung, and ovary. Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.

Purification and Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

Specificity: Nectin 4 polyclonal antibody detects endogenous levels of Nectin 4 protein.

Extra Notes: Western blot (WB) analysis of Nectin 4 polyclonal antibody at 1:500 dilution
LaneA:Hela whole cell lysate
LaneB:MCF-7 whole cell lysate
LaneC:PC12 whole cell lysate

Bioworld Molecular Weight: ~ 66 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; NECTIN4; LNIR; PRR4; PVRL4

Immunogen: Synthetic peptide, corresponding to Human Nectin 4.

Conjugate: Unconjugated

Modification: Unmodified