Nectin 4 rabbit pAb - ES7647

Nectin 4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7647-50, ES7647-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011],

Alternate Name: PVRL4; LNIR; PRR4; Poliovirus receptor-related protein 4; Ig superfamily receptor LNIR; Nectin-4

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 55kD

Human Gene ID: 81607

Human SWISS Prot NO: Q96NY8

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; [Processed poliovirus receptor-related protein 4]: Secreted. The secreted form is found in breast tumor patients (PubMed:15784625).

Research Use Only