NEDD4L Rabbit Polyclonal Antibody - RA33525

NEDD4L Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA33525-50, RA33525-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.08% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2)

Applications: WB

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 23327

Protein MW (KDa): 110-120

SWISS: Q96PU5

Source: Rabbit

Research Use Only