Nephrin Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A27762-20, A27762-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Category: Polyclonal Antibodies
Applications: WB, IF-F, IF-P, IHC-P, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 135kDa
Observed Molecular Weight: 200kDa
Immunogen: Recombinant protein (or fragment) .
Species: Mouse
GeneID: 54631
SWISS: Q9QZS7
Alternate Names: CNF; NPHN; nephrin
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1500 - 1:3000 IF-F, 1:50 - 1:200 IF-P, 1:50 - 1:200 IHC-P, 2000-8000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton.
NCBI Alias: NPHS1
Research Use Only