Nephrin rabbit pAb - ES6411

Nephrin rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6411-50, ES6411-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009],

Alternate Name: NPHS1; NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptor

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Nephrin. AA range:843-892

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 4868

Human SWISS Prot NO: O60500

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.

Research Use Only