Neuregulin-1 SMDF rabbit pAb - ES5736

Neuregulin-1 SMDF rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5736-50, ES5736-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016],

Alternate Name: Pro-neuregulin-1 membrane-bound isoform; Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human NRG1 isoform-10. AA range:1-50

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 44kD

Human Gene ID: 3084

Human SWISS Prot NO: Q02297-10

Subcellular Location: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-1]: Secreted.; [Isoform 8]: Nucleus. May be nuclear.; [Isoform 9]: Secreted. Has a signal peptide.; [Isoform 10]: Membrane; Single-pass type I membrane protein. May possess an internal uncleaved signal sequence.

Research Use Only