Neuregulin-1/SMDF (Y4) Polyclonal Antibody-BS1173

Neuregulin-1/SMDF (Y4) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1173-50, BS1173-100

Sizes: 50µl, 100µl

Swiss-Prot: Q15491

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SMDF/Neuregulin 1 (Y4) polyclonal antibody detects endogenous levels of SMDF/Neuregulin 1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Neuregulin-1 SMDF (Y4) pAb at 1:1000 dilution
Lane 1: PC12 whole cell lysate (40ug)
Lane 2: CT26 whole cell lysate (40ug)
Lane 3: PC3 whole cell lysate (40ug)
Lane 4: SK-OVCAR3 whole cell lysate (40ug)
Lane 5: MCF-7 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Neuregulin-1/SMDF (Y4) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 44 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; Neuregulin-1; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor; NRG1; GGF; HGL; HRGA; NDF; SMDF

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Neuregulin-1/SMDF.

Conjugate: Unconjugated

Modification: Unmodified