Neuregulin-2 rabbit pAb - ES3945

Neuregulin-2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3945-50, ES3945-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010],

Alternate Name: NRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRG2. AA range:361-410

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 90kD

Human Gene ID: 9542

Human SWISS Prot NO: O14511

Subcellular Location: [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-2]: Secreted.

Research Use Only