Neuregulin-3 rabbit pAb - ES8415

Neuregulin-3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8415-50, ES8415-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri

Alternate Name: NRG3; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 80kD

Human Gene ID: 10718

Human SWISS Prot NO: P56975

Subcellular Location: [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-3]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Isoform 3 is also proteolytically released as a soluble form.

Research Use Only