Neurexin I rabbit pAb - ES8030

Neurexin I rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8030-50, ES8030-100

Citations, Manuals and MSDS Available upon request.

Background: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Alternate Name: NRXN1; KIAA0578; Neurexin-1-alpha; Neurexin I-alpha

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 150kD

Human Gene ID: 9378

Human SWISS Prot NO: Q9ULB1

Subcellular Location: Cell junction, synapse, presynaptic cell membrane; Single-pass type I membrane protein.

Research Use Only