Neurofibromin rabbit pAb - ES2930

Neurofibromin rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2930-50, ES2930-100

Citations, Manuals and MSDS Available upon request.

Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: NF1; Neurofibromin; Neurofibromatosis-related protein NF-1

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 319kD

Human Gene ID: 4763

Human SWISS Prot NO: P21359

Subcellular Location: Nucleus. Nucleus, nucleolus.

Research Use Only