Neurophysin I (K40) Polyclonal Antibody-BS3475

Neurophysin I (K40) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3475-50, BS3475-100

Sizes: 50µl, 100µl

Swiss-Prot: P01178

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Neurophysin I (NPI) and neurophysin II (NPII) function as carrier proteins for oxytocin and vasopressin, respectively. Oxytocin is a pituitary hormone which induces uterine contractions during childbirth and the ejection of milk from the mammary glands during nursing. Vasopressin is involved in the metabolism of water and electrolytes and has been identified as a vasoconstrictor. Both neurophysin genes exist as three exons, with each exon encoding a functional protein domain. Studies show that the identically conserved middle region (exon B) is involved in NP-NP homodimer formation as well as being the site for the glycine 17 to valine point mutation responsible for familial diabetes insipidus.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Neurophysin I (K40) polyclonal antibody detects endogenous levels of Neurophysin I protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Neurophysin I (K40) pAb at 1:500 dilution
Lane 1: A549 whole cell lysate (20ug)
Lane 2: SGC7901 whole cell lysate (40ug)
Lane 3: 3T3-L1 whole cell lysate (40ug)
Lane 4: H9C2 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Neurophysin I (K40) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 13 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Oxytocin-neurophysin 1; OT-NPI; Oxytocin; Ocytocin; Neurophysin 1; OXT; OT

Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human Neurophysin I.

Conjugate: Unconjugated

Modification: Unmodified