NFIB/NF1B2 Monoclonal Antibody-MB9384

NFIB/NF1B2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB9384-50, MB9384-100

Product: Mouse IgG2b, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00712(Human) P97863(Mouse)

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: IHC, FC

All Applications: IHC:1:50-1:200
FC:1:50-1:100

Background: NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: NFIB/NF1B2 monoclonal antibody detects endogenous levels of NFIB/NF1B2 protein.

Bioworld Molecular Weight: 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti-NFIB/NF1B2 antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-NFIB/NF1B2 antibody. Counter stained with hematoxylin.

Alternative Name: NF1-B, Nuclear factor 1/B, CTF, NF-I/B, NFI-B, NFIB, CCAAT Box Binding Transcription Factor, CCAAT-box-binding transcription factor, CTF, HMGIC/NFIB, NF-I/B, NF1-B, NF1B, NF1B2, NFI-B, NFI-RED, Nfib, NFIB, NFIB2, NFIB3, Nuclear factor 1 B-type, Nuclear factor 1/B, Nuclear Factor 1B, Nuclear Factor I B, Nuclear factor I/B, TGGCA Binding Protein, TGGCA-binding protein, TRANSCRIPTION FACTOR NFIB,

Immunogen: Recombinant full length protein corresponding to human NFIB/NF1B2.

Conjugate: Unconjugated

Modification: Unmodified