Product Description

Nicastrin Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS47855-50, BS47855-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a type I transmembrane glycoprotein that is an integral component of the mμltimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease, however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the fμll-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, ICC/IF

Alternate Names: ATAG1874

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human Nicastrin

Dilution: WB: 1:1000-1:5000 ICC/IF: 1:20-1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 110-120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q92542

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only