Product Description

NIPA (phospho-S354) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4601-50, BS4601-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumμlates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regμlation. NIPA is normally phosphorylated during G2 and M phases, resμlting in an accumμlation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Nuclear-interacting partner of ALK, Nuclear-interacting partner of anaplastic lymphoma kinase, hNIPA, Zinc finger C3HC-type protein 1, ZC3HC1, NIPA, HSPC216

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Serine 354

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-NIPA (S354) Polyclonal Antibody detects endogenous levels of NIPA protein only when phosphorylated at Ser354.

Molecular Weight: ~ 60-65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q86WB0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only