Product Description

NIPBL Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA33565-50, RA33565-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: NIPBL, cohesin loading factor (NIPBL) Homo sapiens This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section)

Clonality: Polyclonal

Dilution: IHC-p 1:50-300

Molecular Weight: 308

Protein Molecular Weight (kDa): 308

Storage: -20°C/1 year

Human Gene ID: 25836

Human SwissProt Number: Q6KC79

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only