NIPBL rabbit pAb - ES9928

NIPBL rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES9928-50, ES9928-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human protein . at AA range: 560-640

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 308kD

Human Gene ID: 25836

Human SWISS Prot NO: Q6KC79

Subcellular Location: Nucleus. Chromosome.

Research Use Only