Product Description

NMDAε3 (P986) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3541-50, BS3541-100

Sizes: 50µl, 100µl

Swiss-Prot: Q14957

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: ε 1, 2, 3, 4 and one ζ subunit. The ζ subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NMDAε3 (P986) polyclonal antibody detects endogenous levels of NMDAε3 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of NMDAε3 (P986) pAb in paraffin-embedded human liver carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 134 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Glutamate receptor ionotropic; NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C; NMDAR2C; GRIN2C

Immunogen: Synthetic peptide, corresponding to amino acids 956-1008 of Human NMDAε3.

Conjugate: Unconjugated

Modification: Unmodified