NOD1 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA33585-50, RA33585-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009], Reactivity: Human, Mouse Host: Rabbit Applications: WB Alternate Names: Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4) Clonality: Polyclonal Dilution: WB 1:500-2000 Molecular Weight: 105 Protein Molecular Weight (kDa): 105 Storage: -20°C/1 year Human Gene ID: 10392 Human SwissProt Number: Q9Y239 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.224% sodium azide. Research Use Only