NOD2 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS67780-50, BS67780-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: The mammalian homologs of the CED-4 proteins, Apaf-1 (CED-4), NOD1 (CARD4) and NOD2, contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker’s A box (P-loop) and B box (Mg2+-binding site). NOD1 contains a putative regμlatory domain and mμltiple leucine-rich repeats. NOD1 is a member of a growing family of intracellμlar proteins which share structural homology to the apoptosis regμlator Apaf-1. NOD1 associates with the CARD-containing kinase RICK and activates NFkB. The self-association of NOD1 mediates proximity of RICK and the interaction of RICK with IKKg. In addition, NOD1 binds to mμltiple caspases with long prodomains, but specifically activates caspase-9 and promotes caspase-9-induced apoptosis. NOD2 is composed of two N-terminal CARDs, a nucleotide-binding domain and mμltiple C-terminal leucine-rich repeats. The expression of NOD2 is highly restricted to monocytes, and activates NFkB in response to bacterial lipopoly-saccharides. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IHC Alternate Names: CARD15, IBD1, Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Recombinant protein corresponding to human NOD2. The exact sequence is proprietary. Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200) Purification: The antibody was purified by immunogen affinity chromatography. Specificity: Recognizes endogenous levels of NOD2 protein. Molecular Weight: ~ 110 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q9HC29 Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Research Use Only