Noggin Mouse Monoclonal Antibody - RA11755

Noggin Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11755-50, RA11755-100

Citations, Manuals and MSDS Available upon request.

Background: noggin (NOG) Homo sapiens The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4) . By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; ICC

GeneID (Human): 9241

Protein MW (KDa): 26

SWISS: Q13253

Source: Mouse

Research Use Only