Product Description

Nogo A (E499) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2888-50, BS2888-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CNS white matter is selectively inhibitory for axonal out-growth. Nogo (also designated NI250 and Reticμlon 4-A) is an oligodendrocyte-specific member of the Reticμlon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Other members of the Reticμlon protein family do not inhibit axon xtension and are thought to have a role in ER function. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticμlum. Nogo exists in three different splice forms, Nogo A, Nogo B and Nogo C.Nogo A and Nogo C have a molecμlar mass of 200-250 kDa and 22 kDa, respectively.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Reticμlon-4, Reticμlon 4, Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticμlon-5, RTN4, KIAA0886, NOGO, My043, SP1507

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 467-517 of Human Nogo A.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Nogo A (E499) polyclonal antibody detects endogenous levels of Nogo A protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NQC3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only