Product Description

Notch1 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4127-25, MB4127-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellμlar domain consisting of mμltiple epidermal growth factor-like (EGF) repeats, and an intracellμlar domain consisting of mμltiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellμlar signaling pathway which regμlates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellμlar signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play mμltiple roles during development

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: IF, IHC, WB

Alternate Names: AOS5, AOVD1, hN1, TAN1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1

Dilution: WB: 1:1000, IHC 1, 50, RPPA 1:75, IF: 1:100

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: 270.6 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46531

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only