NOTCH4 (Cleaved-Val1467) Rabbit Polyclonal Antibody - RA27909

NOTCH4 (Cleaved-Val1467) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27909-50, RA27909-100

Citations, Manuals and MSDS Available upon request.

Background: notch 4 (NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000

Alternative Names: Neurogenic locus notch homolog protein 4 (Notch 4;hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]

Applications: WB; ELISA

Species Cross-Reactivity: Human; Monkey

GeneID (Human): 4855

Protein MW (KDa): 60 220

SWISS: Q99466

Source: Rabbit

Research Use Only