Product Description

Nova1 Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65682-50, BS65682-100

Swiss-Prot: P51513

Host: Rabbit

Nova1 Polyclonal Antibody-BS65682

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Chicken, Cow,

Applications: WB,

All Applications: WB=1:500-2000

Background: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

Purification and Purity: affinity purified by Protein A

Specificity: Nova1 Polyclonal Antibody detects endogenous levels of Nova1 protein.

Bioworld Molecular Weight: 52 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-Nova1 at 1/1000 dilution, Sample:
DU145 (Human) Cell Lysate at 30 ug
U87MG (Human) Cell Lysate at 30 ug
Primary: Anti- Nova1 at 1/1000 dilution

Alternative Name: Neuro oncological ventral antigen 1; Neuro-oncological ventral antigen 1; NOVA 1; Nova-1; Nova1; NOVA1_HUMAN; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA binding protein Nova 1; RNA-binding protein Nova-1; Ventral neuron specific protein 1; Ventral neuron-specific protein 1.

Immunogen: KLH conjugated synthetic peptide derived from human Nova1

Modification: Unmodified

Conjugate: Unconjugated