Noxa Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90958-50, BS90958-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q13794(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, IHC FC
All Applications: WB:1:500
IHC:1:50-1:200
FC:1:50
Background: Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Noxa polyclonal antibody detects endogenous levels of Noxa protein.
Bioworld Molecular Weight: 6 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Fig1:Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Noxa antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Noxa antibody. Counter stained with hematoxylin.
Alternative Name: PMA-induced protein 1, PMAIP1, NOXA, Adult T cell leukemia derived PMA responsive, APR, APR, ATL-derived, Immediate early response protein APR, Immediate-early-response protein APR, NOXA, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1, PMA-induced protein 1, PMA-responsive gene, Pmaip1, Protein Noxa,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified