NPAS2 Polyclonal Antibody-BS5828

NPAS2 Polyclonal Antibody

Catalogue Numbers: BS5828-50, BS5828-100

Sizes: 50µl, 100µl

Alternative Name: Neuronal PAS domain-containing protein 2; Neuronal PAS2; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; bHLHe9; Member of PAS protein 4; PAS domain-containing protein 4; NPAS2; BHLHE9; MOP4; PASD4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q99743

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family are transcription factors that contain a bHLH DNA binding domain located amino-terminal to a PAS domain. Neuronal PAS domain protein 2 (NPAS2, also designated PAS 4/MOP4) is a member of the bHLH-PAS family and the PAS superfamily. NPAS2, which maps to chromosome 2p11.2-2q13, is expressed primarily in the neurons during the first week of postnatal development. The pattern of NPAS2 expression temporally matches the development of learning and memory, and spatially matches the frontal association/limbic forebrain pathway. NPAS2 may serve a regulatory role in the development and maintenance of long-term memory, and may be required for the processing of complex sensory information. NPAS2 and MOP3 form a transcriptionally active heterodimer which binds to a CACGTGA-containing DNA element and drives transcription from a linked luciferase reporter gene.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NPAS2 polyclonal antibody detects endogenous levels of NPAS2 protein.

Bioworld Molecular Weight: ~ 91 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of NPAS2 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: Raw264.7 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 403-448 of Human NPAS2.

Conjugate: Unconjugated

Modification: Unmodified