Product Description

NPAS4 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61225-50, BS61225-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Per-Arnt-Sim (PAS) domain is a 270 amino acid motif that mediates associations among various PAS family transcription factors. The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2, NPAS3 and NPAS4, which are involved in the development and maintenance of learning and memory pathways. NPAS1 regμlates erythropoietin expression in developing brain. NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription. NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adμlt brain, may be involved in neurogenesis and has been implied to control regμlatory pathways relevant to psychotic illness and schizophrenia. NPAS4 (neuronal PAS domain protein 4), also known as NXF, Le-PAS, PASD10 or bHLHe79, is a 802 amino acid nuclear protein that is exclusively expressed in the brain. NPAS4 acts as a transcriptional activator in the presence of Arnt 1, and activates the CME (CNS midline enhancer) element and expression of the Drebrin gene.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Neuronal PAS domain-containing protein 4, Neuronal PAS4, Class E basic helix-loop-helix protein 79, bHLHe79, HLH-PAS transcription factor NXF, PAS domain-containing protein 10, NPAS4, BHLHE79, NXF, PASD10

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human NPAS4.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NPAS4 polyclonal antibody detects endogenous levels of NPAS4 protein.

Molecular Weight: ~ 87 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8IUM7

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only