NR1H2 Polyclonal Antibody - BT-AP12006

NR1H2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12006-20, BT-AP12006-50, BT-AP12006-100

Citations, Manuals and MSDS Available upon request.

Background: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009

Research Areas: Cardiovascular; Epigenetics and nuclear signaling; Metabolism

Target Protein: NR1H2

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Oxysterols receptor LXR-beta

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P55055; Mouse: Q60644; Rat: Q62755

Synonyms: Oxysterols receptor LXR-beta;Liver X receptor beta;Nuclear receptor NER;Nuclear receptor subfamily 1 group H member 2;Ubiquitously-expressed nuclear receptor

GeneID: Human: 7376

Research Use Only