Product Description

NR2E1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8915-50, BS8915-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y466

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IF IP

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:100

Background: NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NR2E1 polyclonal antibody detects endogenous levels of NR2E1 protein.

Bioworld Molecular Weight: ~ 43kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of various cell lines, using NR2E1 antibody.

Alternative Name: Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; Tll; hTll; NR2E1; TLX

Immunogen: Recombinant full length Human NR2E1.

Conjugate: Unconjugated

Modification: Unmodified