Product Description

NRG1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6037-50, BS6037-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Neuregμlin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregμlin-1 includes a range of isoforms with varying glycosylation, regμlation of expression and function. Neuregμlin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregμlin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregμlin-1 has been linked to schizophrenia and has diverse neural functions. Neuregμlin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregμlate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscμlar junctions.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF/ICC

Alternate Names: GGF, HGL, HRGA, NDF, SMDF, Pro-neuregμlin-1, membrane-bound isoform, Pro-NRG1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NRG1.

Dilution: WB: 1:500~1:1000
IF/ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NRG1 polyclonal antibody detects endogenous levels of NRG1 protein.

Molecular Weight: ~ 70, 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q02297

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only