Product Description

NRG1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS6037-50, BS6037-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q02297

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100

Background: Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NRG1 polyclonal antibody detects endogenous levels of NRG1 protein.

Bioworld Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of NRG1 polyclonal antibody.

Alternative Name: Acetylcholine receptor inducing activity;
Acetylcholine receptor-inducing activity;
ARIA;
Breast cancer cell differentiation factor p45;
ERBB2 p185 activator;
GGF 2;
GGF;
GGF2;
Glial growth factor;
Heregulin alpha;
Heregulin;
heregulin; alpha (45; ERBB2 p185-activator);
HGL;
HRG 1;
HRG;
HRG1;
HRGA;
MST131;
NDF;
Neu differentiation factor;
Neuregulin 1;
neuregulin 1 type IV beta 1a;
neuregulin 1 type IV beta 3;
Neuregulin-1;
Neuregulin1;
NRG 1;
nrg1;
NRG1;
OTTHU

Immunogen: Recombinant full length Human NRG1.

Conjugate: Unconjugated

Modification: Unmodified