Product Description

NSD1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS71397-50, BS71397-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The nuclear receptor-binding SET domain-containing protein 1 (NSD1) belongs to a family of proteins which have all been implicated in human malignancy. The protein family includes NSD2 and NSD3, both of which show 70-75% sequence identity with NSD1 but contribute substantially less to overgrowth phenotypes. Defects and microdeletions of the NSD1 gene are involved in Sotos syndrome, childhood acute myeloid leukemia (AML), Weaver syndrome and Beckwith-Wiedemann Syndrome (BWS). The protein functions as a transcriptional intermediary factor capable of influencing transcription, either negatively or positively, depending on the cellμlar context. NSD1 is a nuclear protein expressed in brain, muscle, spleen, thymus, kidney and, to a lesser extent, lung.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: ARA267, KMT3B, H3-K36-HMTase, H4-K20-HMTase, Lysine N-methyltransferase 3B

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human NSD1.

Dilution: WB 1:500 - 1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: NSD1 polyclonal antibody detects endogenous levels of NSD1 protein.

Molecular Weight: ~ 297 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96L73

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only