NSE2 Polyclonal Antibody - BT-AP12036

NSE2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12036-20, BT-AP12036-50, BT-AP12036-100

Citations, Manuals and MSDS Available upon request.

Background: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,Belongs to the NSE2 family.,Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2/MMS21 and probably NSMCE1.,

Research Areas: Cell biology; Epigenetics and nuclear signaling

Target Protein: NSMCE2

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: E3 SUMO-protein ligase NSE2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96MF7; Mouse: Q91VT1; Rat: Q4V8A0

Synonyms: E3 SUMO-protein ligase NSE2;EC 6.3.2.-;MMS21 homolog;hMMS21;Non-structural maintenance of chromosomes element 2 homolog;Non-SMC element 2 homolog

GeneID: Human: 286053

Research Use Only