Product Description

NTH1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11325-50, MB11325-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P78549

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 34 kDa; Observed MW: 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of NTH1 in Hela using NTH1 antibody, and DAPI., Western blot analysis of NTH1 in K562, Hela lysates using NTH1 antibody.

Alternative Name: FAP3; NTH1; OCTS3; hNTH1

Immunogen: Recombinant protein of human NTH1

Conjugate: Unconjugated

Modification: Unmodified