Product Description

NUAK2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10819-50, ES10819-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: NUAK2,

Specificity: NUAK2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Fetal kidney, Lymph, Teratocarcinoma, Testis,

Observed Band (KD): 69kD

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation:Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. PTM: Autophosphorylated in vitro. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Similarity: Contains 1 protein kinase domain.

Subcellular Location: nucleus, cytoplasm, nuclear speck,

Storage and Stability: -20°C/1 year

Gene Name: NUAK2, OMPHK2, SNARK

Protein Name: NUAK family SNF1-like kinase 2, EC 2.7.11.1, Omphalocele kinase 2, SNF1/AMP kinase-related kinase, SNARK

Human Gene ID: 81788

Human SwissProt Number: Q9H093

Mouse SwissProt Number: Q8BZN4

Rat SwissProt Number: Q66HE5

Research Use Only