NUB1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA27959-50, RA27959-100 Citations, Manuals and MSDS Available upon request. Background: negative regulator of ubiquitin like proteins 1 (NUB1) Homo sapiens This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. Alternative Names: NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18 Applications: WB; IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Mouse; Monkey GeneID (Human): 51667 Protein MW (KDa): 70 SWISS: Q9Y5A7 Source: Rabbit Research Use Only