Nudel Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90974-50, BS90974-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9GZM8(Human) Q78PB6(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
Background: NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: Nudel polyclonal antibody detects endogenous levels of Nudel protein.
Bioworld Molecular Weight: 38 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Nudel on rat brain tissue lysate using anti-Nudel antibody at 1/2,000 dilution., Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Nudel antibody. Counter stained with hematoxylin.
Alternative Name: Protein Nudel, NDEL1, EOPA, MITAP1, NUDEL, A. nidulans, DKFZp451M0318, ENDOOLIGOPEPTIDASE A, EOPA, MITAP 1, MITAP1, Mitosin associated protein 1, Mitosin associated protein MITAP1, Mitosin-associated protein 1, Ndel 1, NDEL1, NDEL1, Nuclear distribution gene E like homolog 1, Nuclear distribution protein nudE like 1, Nuclear distribution protein nudE-like 1, NUDE like protein, NudE nuclear distribution gene E homolog like 1 A. nidulans, NudE nuclear distribution gene E homolog like 1, NUDEL, Protein Nudel,
Conjugate: Unconjugated
Modification: Unmodified