Nup93 Polyclonal Antibody - BT-AP06236

Nup93 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06236-20, BT-AP06236-50, BT-AP06236-100

Citations, Manuals and MSDS Available upon request.

Background: The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup93 (nucleoporin 93) is the most abundant nucleoporin found per NPC, contributing over 10% of the mass. It localizes to the nuclear side of the NPC, predominantly in the basket terminal ring area, and exists in a complex with Nup188, Nup53 and Nup205. This complex is crucial for NPC stability and proper assembly. Nup93 interacts directly with the Nup62 complex located at the center of the NPC and thus tethers the two subcomplexes. Nup93 is composed of a coiled-coil domain at its N-terminus and a C-terminal helical domain. Its proper function is essential for cell viability and normal NPC function.

Research Areas: Others

Target Protein: NUP93

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Nup93 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 93488

UniProt Accession: Human: Q8N1F7; Mouse: Q8BJ71; Rat: Q66HC5

Synonyms: NUP93; KIAA0095; Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93

GeneID: Human: 9688; Mouse: 71805; Rat: 291874

Research Use Only