Product Description

OAS1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7726-50, BS7726-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellμlar protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: (2 5')oligo(A) synthetase 1, (2-5'')oligo(A) synthase 1, 2 5 Oligoadenylate Synthetase 1, 2 5' oligo A synthase 1, 2 5' oligo A synthetase 1, 2 5A synthase 1, 2 5A synthetase 1, 2' 5' oligo A synthetase 1, 2' 5' oligoadenylate synthetase 1 40/46kDa, 2' 5' oligoadenylate synthetase 1, 2' 5' oligoisoadenylate synthetase 1, 2''-5''-oligoadenylate synthase 1, 2'5' oligo A synthetase 1, 2'5' oligoadenylate synthetase 1, 2'5' oligoisoadenylate synthetase 1, 2-5A synthase 1, E18/E16, IFI 4, IFI4, OAS 1, OAS1, OAS1_HUMAN, OIAS, OIASI, p46/p42 OAS,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human OAS1.

Dilution: WB 1:500 - 1:2000
IF 1:50 - 1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.

Molecular Weight: ~ 40 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00973

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only