Product Description

OAS1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7726-50, BS7726-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P00973

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IF

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:100

Background: The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.

Bioworld Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of mouse liver cells, using OAS1 antibody.

Alternative Name: (2 5')oligo(A) synthetase 1;
(2-5'')oligo(A) synthase 1;
2 5 Oligoadenylate Synthetase 1;
2 5' oligo A synthase 1;
2 5' oligo A synthetase 1;
2 5A synthase 1;
2 5A synthetase 1;
2' 5' oligo A synthetase 1;
2' 5' oligoadenylate synthetase 1 40/46kDa;
2' 5' oligoadenylate synthetase 1;
2' 5' oligoisoadenylate synthetase 1;
2''-5''-oligoadenylate synthase 1;
2'5' oligo A synthetase 1;
2'5' oligoadenylate synthetase 1;
2'5' oligoisoadenylate synthetase 1;
2-5A synthase 1;
E18/E16;
IFI 4;
IFI4;
OAS 1;
OAS1;
OAS1_HUMAN;
OIAS;
OIASI;
p46/p42 OAS;

Immunogen: Recombinant full length Human OAS1.

Conjugate: Unconjugated

Modification: Unmodified