OAZ1 Polyclonal Antibody
Catalogue Numbers: BS61230-50, BS61230-100
Sizes: 50µl, 100µl
Alternative Name: Ornithine decarboxylase antizyme 1; ODC-Az; OAZ1; OAZ
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P54368
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Antizyme 1 (AZ1) negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. Polyamines are involved in cell cycle and cell growth, and thus the interaction between AZ1 and ODC functions in this process as well, in a regulatory manner. Furthermore, treatment of cells with leptomycin B, an inhibitor of chromosomal maintenance proteins, causes the relocation of AZ1 to the nucleus, suggesting a novel function of AZ1 not associated with the proteasome.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: OAZ1 polyclonal antibody detects endogenous levels of OAZ1 protein.
Bioworld Molecular Weight: ~ 25 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of OAZ1 polyclonal antibody at 1:500 dilution Lane 1: HEK293T whole cell lysate
Lane 2: RAW264.7 whole cell lysate Lane 3: H9C2 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human OAZ1.
Conjugate: Unconjugated
Modification: Unmodified